The earlier a diagnosis is made and treatment is started, the greater the benefits. But it’s never too late to get help. Treatment for Klinefelter syndrome is based on signs and symptoms and may include:
- Testosterone replacement therapy. Starting at the time of the usual onset of puberty, testosterone replacement therapy can be given to help stimulate changes that normally occur at puberty, such as developing a deeper voice, growing facial and body hair, and increasing muscle mass and sexual desire (libido). Testosterone replacement therapy can also improve bone density and reduce the risk of fractures, and it may improve mood and behavior. It will not improve infertility.
- Speech and physical therapy. These treatments can help boys with Klinefelter syndrome who have problems with speech, language, and muscle weakness.
- Fertility treatment. Most men with Klinefelter syndrome are typically unable to father children because few or no sperm are produced in the testicles. For some men with minimal sperm production, intracytoplasmic sperm injection (ICSI) may be utilized.