How does chromosomal translocation affect fertility?

If the translocation is balanced, meaning that pieces of chromosomes are rearranged but no genetic material is gained or lost in the cell, a carrier usually has no symptoms. Couples, where one of the partners carries translocations, face an increased risk of miscarriages and infertility.
This results from the distribution of chromosomes to reproductive cells during cell divisions which can result in sperm or ova with an abnormal amount of chromosomal material. Disorders of chromosome numbers in reproductive cells can also result in giving birth to a child with a syndrome of congenital defects, e.g. with Down syndrome which is the consequence of translocation between chromosomes 14 and 21 carried by one of the parents.
Typically, people born with Robertsonian translocation are healthy and have average life expectancies. However, depending on the chromosomes involved with this kind of a translocation, you may be at a higher risk for infertility or miscarriage.

 

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